Bloom syndrome: a mendelian prototype of somatic mutational disease.

Abstract excerpt

Spontaneous mutations in human somatic cells occur far more often than normal in individuals with Bloom syndrome. The basis for understanding these mutations and their developmental consequences emerges from examination of BS at the molecular, cellular, and clinical levels. The major clinical fea...

Topics

• Adolescent
• Adult
• Bloom Syndrome
• Child
• Homozygote
• Humans
• Male
• Middle Aged
• Mutation
• Neoplasms
• Phenotype