Article
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms in Parkinson's disease and age of onset.
Neuroscience letters - 15 Dec 2003
Hong Chen-Jee, Liu Hsiu-Chih, Liu Tsung-Yun, Lin Ching-Hua, Cheng Chih-Ya, Tsai Shih-Jen
Abstract excerpt
Given the implications with respect to neuronal survival and the decreased level of the protein in the striatal region in Parkinson's disease (PD), brain-derived neurotrophic factor (BDNF) may be a candidate gene conferring susceptibility to PD. In a recent study of a Japanese population, a functional BDNF Val66Met polymorphism was associated with PD, however, an analogous investigation of a western population...
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