Article
BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease.
Neuroscience letters - 21 Feb 2014
Białecka Monika, Kurzawski Mateusz, Roszmann Anna, Robowski Piotr, Sitek Emilia J, Honczarenko Krystyna, Mak Monika, Deptuła-Jarosz Monika, Gołąb-Janowska Monika, Droździk Marek, Sławek Jarosław
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is a neurotrophin widely expressed in the mammalian brain, regulating neuronal survival and known to influence dopaminergic neurons and cognitive processes. The present study investigated the BDNF Val66Met polymorphism associations with PD risk, and cognitive impairment in PD. A total of 486 study subjects (244 PD and 242 age and sex matched controls) were included in the...
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