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Article

Interaction between extracellular Hanatoxin and the resting conformation of the voltage-sensor paddle in Kv channels.

Neuron - 30 Oct 2003

Lee Hwa C, Wang Julia M, Swartz Kenton J

Abstract excerpt

In voltage-activated potassium (Kv) channels, basic residues in S4 enable the voltage-sensing domain to move in response to membrane depolarization and thereby trigger the activation gate to open. In the X-ray structure of the KvAP channel, the S4 helix is located near the intracellular boundary of the membrane where it forms a "voltage-sensor paddle" motif with the S3b helix. It has been proposed that the paddle...

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Identifiers

PMID: 14642277
DOI: 10.1016/s0896-6273(03)00636-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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