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Article

Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels.

Neuron - 1 Apr 1997

Swartz K J, MacKinnon R

Abstract excerpt

Hanatoxin (HaTx) binds to multiple sites on the surface of the drk1 voltage-gated K+ channel and modifies channel gating. We set out to identify channel residues that contribute to form these HaTx binding sites. Chimeras constructed using the drk1 and shaker K+ channels suggest that the S3-S4 linker may contain influential residues. Alanine scanning mutagenesis of the region extending from the C terminal end of...

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PMID: 9136775
DOI: 10.1016/s0896-6273(00)80307-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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