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Article

Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity.

PloS one - 1 Jan 2012

Lin Tao, Gao Lihui, Zhang Chuhua, Odeh Evelyn, Jacobs Mary B, Coutte Loïc, Chaconas George, Philipp Mario T, Norris Steven J

Abstract excerpt

The identification of genes important in the pathogenesis of Lyme disease Borrelia has been hampered by exceedingly low transformation rates in low-passage, infectious organisms. Using the infectious, moderately transformable B. burgdorferi derivative 5A18NP1 and signature-tagged versions of the Himar1 transposon vector pGKT, we have constructed a defined transposon library for the efficient genome-wide...

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PMID: 23133514
DOI: 10.1371/journal.pone.0047532
PMCID: PMC3485029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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