Global Tn‐seq analysis of carbohydrate utilization and vertebrate infectivity of <i>Borrelia burgdorferi</i>

Abstract excerpt

Borrelia burgdorferi maintains a complex life cycle between tick and vertebrate hosts. Although some genes have been identified as contributing to bacterial adaptation in the different hosts, the list is incomplete. In this manuscript, we report the first use of transposon mutagenesis combined with high-throughput sequencing (Tn-seq) in B. burgdorferi. We utilize the technique to investigate mechanisms of...

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