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Article

The alpha-subunit of the heterotrimeric G protein G13 activates a phospholipase D isozyme by a pathway requiring Rho family GTPases.

The Journal of biological chemistry - 27 Feb 1998

Plonk S G, Park S K, Exton J H

Abstract excerpt

G13 belongs to the G12 family of heterotrimeric G proteins, whose effectors are poorly defined. The present study was designed to test if phospholipase D (PLD) is regulated by G13 and if Rho-type small GTPases are involved. Expression of the constitutively active Q226L mutant of the alpha-subunit of G13 in COS-7 cells stimulated the activity of a rat brain phospholipase D isozyme (rPLD1) co-expressed in the...

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Identifiers

PMID: 9478920
DOI: 10.1074/jbc.273.9.4823

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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