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Article

Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2003

Tanaka Sumiaki, Edberg Jeffrey C, Chatham Winn, Fassina Giorgio, Kimberly Robert P

Abstract excerpt

Antineutrophil cytoplasmic Abs (ANCA) can activate neutrophils in an FcgammaR-dependent manner, but the link between this ANCA-induced effect and mononuclear cell activation with the characteristic granuloma formation of Wegener's granulomatosis is unclear. Human alpha-defensins, small cationic antimicrobial peptides, are found in neutrophils and have chemotactic activity for T cells, dendritic cells, and...

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Identifiers

PMID: 14634123
DOI: 10.4049/jimmunol.171.11.6090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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