Cytogenetic challenge assays for assessment of DNA repair capacities.

doi:10.1385/1-59259-973-7:025

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Article

Cytogenetic challenge assays for assessment of DNA repair capacities.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006

Au William W, Salama Salama A

Abstract excerpt

Different challenge assays have been used to investigate cellular responses following exposure to DNA damaging agents. Our protocol uses X- or gamma-rays or ultraviolet light to challenge cells to repair the induced damage, and chromosome aberrations as a biomarker to indicate DNA repair proficiency. The assay was used successfully to demonstrate base- and nucleotide-excision repair deficiency in certain...

Topics

Cells, Cultured
Chromosome Aberrations
Cytogenetic Analysis
DNA
DNA Damage
DNA Repair
DNA-Binding Proteins
Environmental Exposure
Humans
Lymphocytes
Mining
Mutagens
Mutation
Radiation, Ionizing
Smoking
Uranium
X-ray Repair Cross Complementing Protein 1
Xeroderma Pigmentosum Group D Protein

Source

Open in PubMed

Identifiers

PMID: 16673871
DOI: 10.1385/1-59259-973-7:025

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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