Article
The transcription factor Eyes absent is a protein tyrosine phosphatase.
Nature - 20 Nov 2003
Tootle Tina L, Silver Serena J, Davies Erin L, Newman Victoria, Latek Robert R, Mills Ishara A, Selengut Jeremy D, Parlikar Beth E W, Rebay Ilaria
Abstract excerpt
Post-translational modifications provide sensitive and flexible mechanisms to dynamically modulate protein function in response to specific signalling inputs. In the case of transcription factors, changes in phosphorylation state can influence protein stability, conformation, subcellular localization, cofactor interactions, transactivation potential and transcriptional output. Here we show that the evolutionarily...
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