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Article

Eyes absent represents a class of protein tyrosine phosphatases.

Nature - 20 Nov 2003

Rayapureddi Jayanagendra P, Kattamuri Chandramohan, Steinmetz Brian D, Frankfort Benjamin J, Ostrin Edwin J, Mardon Graeme, Hegde Rashmi S

Abstract excerpt

The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye, muscle, kidney and ear. Mutations in the Eyes absent genes have been associated with several congenital disorders including the multi-organ disease bronchio-oto-renal syndrome, congenital cataracts and late-onset deafness. On the basis of previous analyses it has been shown that Eyes absent is a...

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Source

Identifiers

PMID: 14628052
DOI: 10.1038/nature02093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Eyes absent represents a class of protein tyrosine phosphatases.PMID 14628052Read ↗

The transcription factor Eyes absent is a protein tyrosine phosphatase.Semantic proximity Read ↗

Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival.Semantic proximity Read ↗

The Eyes Absent proteins in development and in developmental disorders.Semantic proximity Read ↗

Multiple roles of the eyes absent gene in Drosophila.Semantic proximity Read ↗

Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm.Semantic proximity Read ↗

Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity.Semantic proximity Read ↗

Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain.Semantic proximity Read ↗

Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent.Semantic proximity Read ↗

Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.Semantic proximity Read ↗

Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.Semantic proximity Read ↗

The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates.Semantic proximity Read ↗

The C. elegans eyes absent ortholog EYA-1 is required for tissue differentiation and plays partially redundant roles with PAX-6.Semantic proximity Read ↗

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