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Article

Tissue inhibitor of metalloproteinases 3-dependent microvascular endothelial cell barrier function is disrupted under septic conditions.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2016

Arpino Valerie, Mehta Sanjay, Wang Lefeng, Bird Ryan, Rohan Marta, Pape Cynthia, Gill Sean E

Abstract excerpt

Sepsis is associated with dysfunction of microvascular endothelial cells (MVEC) leading to tissue edema and multiple organ dysfunction. Metalloproteinases can regulate MVEC function through processing of cell surface proteins, and tissue inhibitor of metalloproteinases 3 (TIMP3) regulates metalloproteinase activity in the lung following injury. We hypothesize that TIMP3 promotes normal pulmonary MVEC barrier...

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Identifiers

PMID: 26993226
DOI: 10.1152/ajpheart.00796.2015

Genes

TIMP3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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