Article
GDF3 Protects Mice against Sepsis-Induced Cardiac Dysfunction and Mortality by Suppression of Macrophage Pro-Inflammatory Phenotype.
Cells - 3 Jan 2020
Wang Lu, Li Yutian, Wang Xiaohong, Wang Peng, Essandoh Kobina, Cui Shunan, Huang Wei, Mu Xingjiang, Liu Zhenling, Wang Yigang, Peng Tianqing, Fan Guo-Chang
Abstract excerpt
Macrophages are critical for regulation of inflammatory response during endotoxemia and septic shock. However, the mediators underlying their regulatory function remain obscure. Growth differentiation factor 3 (GDF3), a member of transforming growth factor beta (TGF-β) superfamily, has been implicated in inflammatory response. Nonetheless, the role of GDF3 in macrophage-regulated endotoxemia/sepsis is unknown....
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