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Article

Disease-associated variants in PYPAF1 and NOD2 result in similar alterations of conserved sequence.

Bioinformatics (Oxford, England) - 22 Nov 2003

Albrecht Mario, Lengauer Thomas, Schreiber Stefan

Abstract excerpt

Sequence variations in the gene products PYPAF1/CIAS1 and NOD2/CARD15 have been associated with several autoinflammatory diseases that, although clinically different, share a similar inflammatory pathophysiology. A multiple sequence alignment of homologous proteins demonstrates that some of the m...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to NLR Family, Pyrin Domain-Containing 3 Protein

Share to Nod2 Signaling Adaptor Protein

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Source

Identifiers

PMID: 14630645
DOI: 10.1093/bioinformatics/btg370

Genes

NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14630645-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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