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Article

A Novel Mutation in the NBD Domain of NLRC4 Causes Mild Autoinflammation With Recurrent Urticaria.

Frontiers in immunology - 1 Jan 2021

Wang Li, Wen Wen, Deng Mengyue, Li Yue, Sun Gan, Zhao Xiaodong, Tang Xuemei, Mao Huawei

Abstract excerpt

Background: NOD-like receptor family CARD-containing 4 protein (NLRC4) is a cytosolic protein that forms an inflammasome in response to flagellin and type 3 secretion system (T3SS) proteins from invading Gram-negative bacteria. NLRC4 mutations have been recently identified in early-onset severe autoinflammatory disorders. In this study, we reported a novel mutation in NLRC4 in two Chinese patients, who manifested...

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Source

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Identifiers

PMID: 34248956
DOI: 10.3389/fimmu.2021.674808
PMCID: PMC8260849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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