Article
Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder - Blau syndrome.
Advances in protein chemistry and structural biology - 1 Jan 2020
Thirumal Kumar D, Udhaya Kumar S, Nishaat Laeeque Ahmed Shaikh, Apurva Abhay Shivalkar, Bithia R, Magesh R, Kumar Maignana, Zayed Hatem, George Priya Doss C
Abstract excerpt
Blau syndrome (BS), which affects the eyes, skin, and joints, is an autosomal dominant genetic inflammatory disorder. BS is caused by mutations in the NOD2 gene. However, there are no direct treatments, and treatment with conventional anti-inflammatory drugs such as adrenal glucocorticoids, anti-metabolites, and biological agents such as anti-TNF and infliximab have all been attempted with varying degrees of...
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