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Article

Glycine-modulating Slc6a20a-ASO restores NMDA receptor function in SHANK2 and SHANK3-mutant mice and cortical organoids.

Nature communications - 29 May 2026

Roh Junyeop Daniel, Bae Mihyun, Oh Yusang, Yang Yeji, Lee Suho, Hwang Woo-Chang, Yang Esther, Kim Hyeonji, Jang Hyunjee, Choi Hyung-Wook, Kim Hyun, Kim Jin Young, Kim Eunjoon

Abstract excerpt

Suppressed NMDA receptor (NMDAR) function contributes to multiple brain disorders, including schizophrenia, autism spectrum disorder (ASD), and NMDAR encephalitis. Previous attempts to restore NMDAR activity by increasing ambient glycine, a critical co-agonist, through GlyT1 inhibition have yielded mixed outcomes, partly due to GlyT1's extensive expression in essential brainstem regions. Slc6a20a, a glycine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42215483
DOI: 10.1038/s41467-026-73881-9
PMCID: PMC13392139

Genes

SLC6A20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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