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Article

Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a procognitive and antipsychotic phenotypic profile.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Mar 2006

Yee Benjamin K, Balic Ela, Singer Philipp, Schwerdel Cornelia, Grampp Thomas, Gabernet Laetitia, Knuesel Irene, Benke Dietmar, Feldon Joram, Mohler Hanns, Boison Detlev

Abstract excerpt

The NMDA receptor is thought to play a central role in some forms of neuronal plasticity, including the induction of long-term potentiation. NMDA receptor hypofunction can result in mnemonic impairment and has been implicated in the cognitive symptoms of schizophrenia. The activity of NMDA receptors is controlled by its endogenous coagonist glycine, and a local elevation of glycine levels is expected to enhance...

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Identifiers

PMID: 16554468
DOI: 10.1523/JNEUROSCI.5120-05.2006
PMCID: PMC6674096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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