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Article

Fitness effects of DHFR-TS mutations associated with pyrimethamine resistance in apicomplexan parasites.

Molecular microbiology - 1 Nov 2003

Fohl Leah M, Roos David S

Abstract excerpt

Pyrimethamine resistance in the malaria parasite Plasmodium falciparum is characterized by specific point mutations in the dihydrofolate reductase (DHFR) domain of the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) gene. We have previously explored the effect of these mutations by engineering homologous alleles of Toxoplasma gondii DHFR-TS, which can readily be expressed as recombinant...

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Source

Identifiers

PMID: 14622418
DOI: 10.1046/j.1365-2958.2003.03756.x

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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