Article
Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.
Antimicrobial agents and chemotherapy - 1 Nov 2006
Bunyarataphan Sasinee, Leartsakulpanich Ubolsree, Taweechai Supannee, Tarnchompoo Bongkoch, Kamchonwongpaisan Sumalee, Yuthavong Yongyuth
Abstract excerpt
Pyrimethamine analogs were examined as potential agents against vivax malaria using a bacterial surrogate system carrying Plasmodium vivax dihydrofolate reductase-thymidylate synthase (PvDHFR-TS), in which the PvDHFR complemented chemically knocked out host dihydrofolate reductase. The system was initially tested with P. falciparum dihydrofolate reductase-thymidylate synthase and was found to have good...
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