Article
Pharmacokinetics and pharmacodynamics of mivacurium in patients phenotypically heterozygous for the usual and atypical plasma cholinesterase variants (UA).
Acta anaesthesiologica Scandinavica - 1 Nov 2003
Østergaard D, Viby-Mogensen J, Rasmussen S N, Gätke M R, Pedersen N A, Skovgaard L T
Abstract excerpt
BACKGROUND: Mivacurium is hydrolyzed by plasma cholinesterase (pChe). The purpose of this study was to evaluate the pharmacodynamics and the pharmacokinetics of the three isomers of mivacurium in patients phenotypically heterozygous for the usual and the atypical pChe variant (UA). METHODS: Thirty-two patients were included in a dose-response study, in which the patients received one of four doses of mivacurium....
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