Article
Response to mivacurium in a patient compound heterozygous for a novel and a known silent mutation in the butyrylcholinesterase gene: genotyping by sequencing.
Anesthesiology - 1 Sept 2001
Gätke M R, Ostergaard D, Bundgaard J R, Varin F, Viby-Mogensen J
Abstract excerpt
BACKGROUND: Patients who are homozygous for the atypical mutation, compound heterozygous for atypical and silent mutations, or homozygous for silent mutations (SS) respond to mivacurium with extensively prolonged neuromuscular block. Although important, exact phenotyping of these patients is difficult. This article presents the pharmacodynamics and pharmacokinetics of a normal dose of mivacurium in a patient with...
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