Article
Response to mivacurium in patients carrying the k variant in the butyrylcholinesterase gene.
Anesthesiology - 1 Mar 2005
Gätke Mona R, Viby-Mogensen Jørgen, Ostergaard Doris, Bundgaard Jens R
Abstract excerpt
BACKGROUND: Mivacurium is hydrolyzed by the butyrylcholinesterase enzyme, and patients with hereditary changes of the enzyme often have prolonged duration of action of mivacurium. In this study, the authors investigated the significance of the most commonly occurring variant, the Kalow (K) variant, established using DNA analysis, for the response to mivacurium. METHODS: A total of 58 patients carrying either the...
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