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Article

Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.

The Journal of biological chemistry - 6 Feb 2004

Hartner Jochen C, Schmittwolf Carolin, Kispert Andreas, Müller Albrecht M, Higuchi Miyoko, Seeburg Peter H

Abstract excerpt

ADAR1 (adenosine deaminase acting on RNA-1) is widely expressed in mammals, but its biological role is unknown. We show here by gene targeting that ADAR1 selectively edits in vivo two of five closely spaced adenosines in the serotonin 5-hydroxytryptamine subtype 2C receptor pre-mRNA of nervous tissue; and hence, site-selective adenosine-to-inosine editing is indeed a function of ADAR1. Remarkably, homozygosity...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14615479
DOI: 10.1074/jbc.M311347200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.PMID 14615479Read ↗

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