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Article

RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.

PLoS genetics - 1 May 2021

Kim Jung In, Nakahama Taisuke, Yamasaki Ryuichiro, Costa Cruz Pedro Henrique, Vongpipatana Tuangtong, Inoue Maal, Kanou Nao, Xing Yanfang, Todo Hiroyuki, Shibuya Toshiharu, Kato Yuki, Kawahara Yukio

Abstract excerpt

Adenosine deaminase acting on RNA 1 (ADAR1), an enzyme responsible for adenosine-to-inosine RNA editing, is composed of two isoforms: nuclear p110 and cytoplasmic p150. Deletion of Adar1 or Adar1 p150 genes in mice results in embryonic lethality with overexpression of interferon-stimulating genes (ISGs), caused by the aberrant recognition of unedited endogenous transcripts by melanoma differentiation-associated...

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Identifiers

PMID: 33983932
DOI: 10.1371/journal.pgen.1009516
PMCID: PMC8118328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA editing at a limited number of sites is sufficient to prevent MDA5 activation in the mouse brain.PMID 33983932Read ↗

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