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Article

Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

Science (New York, N.Y.) - 1 Dec 2000

Wang Q, Khillan J, Gadue P, Nishikura K

Abstract excerpt

The members of the ADAR (adenosine deaminase acting on RNA) gene family are involved in site-selective RNA editing that changes adenosine residues of target substrate RNAs to inosine. Analysis of staged chimeric mouse embryos with a high contribution from embryonic stem cells with a functional null allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype. Most ADAR1+/- chimeric embryos died before...

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Source

Identifiers

PMID: 11099415
DOI: 10.1126/science.290.5497.1765

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.PMID 11099415Read ↗

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.Semantic proximity Read ↗

ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.Semantic proximity Read ↗

Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.Semantic proximity Read ↗

Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.Semantic proximity Read ↗

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human DiseasesSemantic proximity Read ↗

Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisSemantic proximity Read ↗

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.Semantic proximity Read ↗

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.Semantic proximity Read ↗

Antagonistic and stimulative roles of ADAR1 in RNA silencing.Semantic proximity Read ↗

The Editor's I on Disease Development.Semantic proximity Read ↗

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signalingSemantic proximity Read ↗

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.Semantic proximity Read ↗

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