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Article

Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.

Science (New York, N.Y.) - 1 Dec 2000

Wang Q, Khillan J, Gadue P, Nishikura K

Abstract excerpt

The members of the ADAR (adenosine deaminase acting on RNA) gene family are involved in site-selective RNA editing that changes adenosine residues of target substrate RNAs to inosine. Analysis of staged chimeric mouse embryos with a high contribution from embryonic stem cells with a functional null allele for ADAR1 revealed a heterozygous embryonic-lethal phenotype. Most ADAR1+/- chimeric embryos died before...

Topics

Adenosine Deaminase
Alleles
Animals
Chimera
Embryonic and Fetal Development
Erythroblasts
Erythropoiesis
Female
Hematopoietic Stem Cells
Hepatocytes
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Liver

Mice

Mice, Inbred BALB C

Mice, SCID

Phenotype

RNA Editing

RNA-Binding Proteins

Source

Identifiers

PMID: 11099415
DOI: 10.1126/science.290.5497.1765

Genes

ADAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.PMID 11099415Read ↗

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.Semantic proximity Read ↗

ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.Semantic proximity Read ↗

Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.Semantic proximity Read ↗

Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.Semantic proximity Read ↗

Functions of the RNA Editing Enzyme ADAR1 and Their Relevance to Human DiseasesSemantic proximity Read ↗

Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisSemantic proximity Read ↗

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.Semantic proximity Read ↗

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.Semantic proximity Read ↗

Antagonistic and stimulative roles of ADAR1 in RNA silencing.Semantic proximity Read ↗

The Editor's I on Disease Development.Semantic proximity Read ↗

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signalingSemantic proximity Read ↗

The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.Semantic proximity Read ↗

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