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Article

ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.

Proceedings of the National Academy of Sciences of the United States of America - 20 Oct 2009

XuFeng Richard, Boyer Matthew J, Shen Hongmei, Li Yanxin, Yu Hui, Gao Yindai, Yang Qiong, Wang Qingde, Cheng Tao

Abstract excerpt

Adenosine Deaminase Acting on RNA 1 (ADAR1) is an RNA-editing enzyme that converts adenosine to inosine, following RNA transcription. ADAR1's essential role in embryonic development, especially within the hematopoietic lineage, has been demonstrated in knock-out mice. However, a specific role for ADAR1 in adult hematopoietic progenitor cells (HPCs) remains elusive. In this report, we show that ADAR1 is required...

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Identifiers

PMID: 19805087
DOI: 10.1073/pnas.0903324106
PMCID: PMC2764897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ADAR1 is required for hematopoietic progenitor cell survival via RNA editing.PMID 19805087Read ↗

Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis.Semantic proximity Read ↗

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.Semantic proximity Read ↗

Deletion of the RNA‐editing enzyme ADAR1 causes regression of established chronic myelogenous leukemia in miceSemantic proximity Read ↗

ADAR1 is vital for B cell lineage development in the mouse bone marrowSemantic proximity Read ↗

Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1.Semantic proximity Read ↗

ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signalingSemantic proximity Read ↗

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.Semantic proximity Read ↗

Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.Semantic proximity Read ↗

Generation of a new <i> Adar1p150 <sup>-/-</sup> </i> mouse demonstrates isoform-specific roles in embryonic development and adult homeostasisSemantic proximity Read ↗

Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.Semantic proximity Read ↗

ADAR1, inosine and the immune sensing system: distinguishing self from non-self.Semantic proximity Read ↗

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapySemantic proximity Read ↗

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