Article
Biomolecular interactions between human recombinant beta-MyHC and cMyBP-Cs implicated in familial hypertrophic cardiomyopathy.
Cardiovascular research - 1 Nov 2003
Flavigny Jeanne, Robert Philippe, Camelin Jean-Claude, Schwartz Ketty, Carrier Lucie, Berrebi-Bertrand Isabelle
Abstract excerpt
OBJECTIVE: Cardiac myosin-binding protein C (cMyBP-C) is a component of sarcomere that contains at least three putative myosin-binding sites. Mutations in its gene are implicated in familial hypertrophic cardiomyopathy (FHC) and most of them are predicted to produce C-terminal truncated cMyBP-Cs. The aim of the present study was to analyze whether cMyBP-C truncated mutants resulting from FHC mutations interact in...
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