Article
Rapid, stabilizing palindrome rearrangements in somatic cells by the center-break mechanism.
Molecular and cellular biology - 1 Dec 2003
Cunningham Lesley A, Coté Atina G, Cam-Ozdemir Cennet, Lewis Susanna M
Abstract excerpt
DNA palindromes are associated with rearrangement in a variety of organisms. A unique opportunity to examine the impact of a long palindrome in mammals is afforded by the Line 78 strain of mice. Previously it was found that the transgene in Line 78 is likely to be palindromic and that the symmetry of the transgene was responsible for a high level of germ line instability. Here we prove that Line 78 mice harbor a...
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