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Article

Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal Translocation

25 Jan 2012

Abstract excerpt

The t(14;18) translocation in follicular lymphoma is one of the most common chromosomal translocations. Breaks in chromosome 18 are localized at the 3'-UTR of BCL2 gene or downstream and are mainly clustered in either the major breakpoint region or the minor breakpoint cluster region (mcr). The recombination activating gene (RAG) complex induces breaks at IgH locus of chromosome 14, whereas the mechanism of...

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PMID: 22275374
DOI: 10.1074/jbc.m111.307363

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Related research

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Mechanism of Fragility at BCL2 Gene Minor Breakpoint Cluster Region during t(14;18) Chromosomal TranslocationPMID 22275374Read ↗

DNA structural basis for fragility at peak III of BCL2 major breakpoint region associated with t(14;18) translocation.Semantic proximity Read ↗

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