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Article

Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells.

Biochemical and biophysical research communications - 28 Mar 2003

Zhou Chenyi, Liu Jinsong

Abstract excerpt

Human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, is responsible for the synthesis and maintenance of the telomeric repeats at the distal ends of human chromosomes. Telomerase expression is repressed in normal human cells and is activated in immortal cells and during tumorigenesis, but the mechanism by which telomerase expression is regulated is not fully understood....

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Source

Identifiers

PMID: 12646176
DOI: 10.1016/s0006-291x(03)00318-8

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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