Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Resistance to telomerase inhibition by human squamous cell carcinoma cell lines.

International journal of oncology - 1 Apr 2011

Bojovic Bojana, Crowe David L

Abstract excerpt

Telomeres are nucleoprotein structures at the ends of chromosomes that are composed of a repetitive G rich sequence and telomeric binding proteins. Telomeres prevent the degradation of chromosomal ends and protect against inappropriate recombination. Telomere attrition involves a tumor suppressor pathway that limits the replication of premalignant cells. The loss of telomeric DNA with each round of replication...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Carcinoma, Squamous Cell
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Mutant Proteins

Share to Naphthalenes

Share to Telomerase

Source

Identifiers

PMID: 21305252
DOI: 10.3892/ijo.2011.935

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Resistance to telomerase inhibition by human squamous cell carcinoma cell lines.PMID 21305252Read ↗

Efficient Inhibition of Human Telomerase Reverse Transcriptase Expression by RNA Interference Sensitizes Cancer Cells to Ionizing Radiation and ChemotherapySemantic proximity Read ↗

Inhibition of telomerase limits the growth of human cancer cells.Semantic proximity Read ↗

Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells.Semantic proximity Read ↗

Rapid Inhibition of Cancer Cell Growth Induced by Lentiviral Delivery and Expression of Mutant-Template Telomerase RNA and Anti-telomerase Short-Interfering RNASemantic proximity Read ↗

Down-regulation of human telomerase reverse transcriptase through specific activation of RNAi pathway quickly results in cancer cell growth impairmentSemantic proximity Read ↗

Telomerase inhibition by an siRNA directed against hTERT leads to telomere attrition in HT29 cellsSemantic proximity Read ↗

Specific Association of Human Telomerase Activity with Immortal Cells and CancerSemantic proximity Read ↗

A highly selective telomerase inhibitor limiting human cancer cell proliferationSemantic proximity Read ↗

Mutated telomeres sensitize tumor cells to anticancer drugs independently of telomere shortening and mechanisms of telomere maintenance.Semantic proximity Read ↗

CRISPR/Cas9-Mediated TERT Disruption in Cancer CellsSemantic proximity Read ↗

Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cellsSemantic proximity Read ↗

Immortalization of human small airway epithelial cells by ectopic expression of telomeraseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.