Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERT

15 Mar 2002

Abstract excerpt

Telomerase is believed to be induced upon proliferation and inhibited when cells differentiate. Thus, regulation of telomerase activity could be an important mechanism to limit growth of normal and cancer cells. Using transforming growth factor-beta 1 (TGF-beta1), which is known to control proliferation in epithelial cells, we now demonstrate that in the human HaCaT skin keratinocytes, TGF-beta1 downregulated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Corneal Surgery and Treatments
Share to Mesenchymal stem cell research
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11884529
DOI: 10.1242/jcs.115.6.1305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dual regulation of telomerase activity through c-Myc-dependent inhibition and alternative splicing of hTERTPMID 11884529Read ↗

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase ActivitySemantic proximity Read ↗

Expression of the telomerase catalytic subunit, hTERT, induces resistance to transforming growth factor β growth inhibition in p16 <sup>INK4A</sup> (−) human mammary epithelial cellsSemantic proximity Read ↗

Dissecting the non-canonical functions of telomerase.Semantic proximity Read ↗

Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation.Semantic proximity Read ↗

hTERT promotes cell adhesion and migration independent of telomerase activity.Semantic proximity Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

BRCA1 Inhibition of Telomerase Activity in Cultured CellsSemantic proximity Read ↗

TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytesSemantic proximity Read ↗

Tissue-specific alternate splicing of human telomerase reverse transcriptase (hTERT) influences telomere lengths during human developmentSemantic proximity Read ↗

Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cellsSemantic proximity Read ↗

Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.Semantic proximity Read ↗

TGF‐β regulation of epithelial cell proliferationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.