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Article

Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.

Molecular and cellular biology - 1 Dec 2003

von Kobbe Cayetano, Harrigan Jeanine A, May Alfred, Opresko Patricia L, Dawut Lale, Cheng Wen-Hsing, Bohr Vilhelm A

Abstract excerpt

A defect in the Werner syndrome protein (WRN) leads to the premature aging disease Werner syndrome (WS). Hallmark features of cells derived from WS patients include genomic instability and hypersensitivity to certain DNA-damaging agents. WRN contains a highly conserved region, the RecQ conserved domain, that plays a central role in protein interactions. We searched for proteins that bound to this region, and the...

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Source

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Identifiers

PMID: 14612404
DOI: 10.1128/MCB.23.23.8601-8613.2003
PMCID: PMC262662

Genes

WRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.PMID 14612404Read ↗

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome proteinSemantic proximity Read ↗

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Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.Semantic proximity Read ↗

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