Article
Immunogenetic predisposing factors for mesial temporal lobe epilepsy with hippocampal sclerosis.
The International journal of neuroscience - 1 Apr 2018
Leal Bárbara, Chaves João, Carvalho Cláudia, Bettencourt Andreia, Brito Cláudia, Boleixa Daniela, Freitas Joel, Brás Sandra, Lopes João, Ramalheira João, Costa Paulo P, da Silva Berta Martins, da Silva António Martins
Abstract excerpt
PURPOSE: Neuroinflammation appears as an important epileptogenic mechanism. Experimental and clinical studies have demonstrated an upregulation of pro-inflammatory cytokines such as IL-1β and TNF-α, in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Expression of these cytokines can be modulated by polymorphisms such as rs16944 and rs1800629, respectively, both of which have been associated...
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