Article
Haplotype mapping of the bronchiolitis susceptibility locus near IL8.
Human genetics - 1 Feb 2004
Hull Jeremy, Rowlands Kate, Lockhart Elizabeth, Sharland Mike, Moore Catrin, Hanchard Neil, Kwiatkowski Dominic P
Abstract excerpt
Susceptibility to viral bronchiolitis, the commonest cause of infant admissions to hospital in the industrialised world, is associated with polymorphism at the IL8 locus. Here we map the genomic boundaries of the disease association by case-control analysis and TDT in 580 affected UK infants. Markers for association mapping were chosen after determining patterns of linkage disequilibrium across the surrounding...
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