Article
Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster.
Thorax - 1 Apr 2009
Forton J T, Rowlands K, Rockett K, Hanchard N, Herbert M, Kwiatkowski D P, Hull J
Abstract excerpt
BACKGROUND: The pathophysiological basis of severe respiratory syncytial virus (RSV) bronchiolitis in infancy is poorly understood and has hindered vaccine development. Studies implicate the cell-mediated immune response in the pathogenesis of the disease. A recent twin study estimated a heritable contribution of 22% to RSV bronchiolitis. Genetic epidemiology provides a new approach to identifying important...
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