Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

doi:10.1371/journal.pone.0003665

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Article

Association of interacting genes in the toll-like receptor signaling pathway and the antibody response to pertussis vaccination.

PloS one - 1 Jan 2008

Kimman Tjeerd G, Banus Sander, Reijmerink Naomi, Reimerink Johan, Stelma Foekje F, Koppelman Gerard H, Thijs Carel, Postma Dirkje S, Kerkhof Marjan

Abstract excerpt

BACKGROUND: Activation of the Toll-like receptor (TLR) signaling pathway through TLR4 may be important in the induction of protective immunity against Bordetella pertussis with TLR4-mediated activation of dendritic and B cells, induction of cytokine expression, and reversal of tolerance as crucial steps. We examined whether single nucleotide polymorphisms (SNPs) in genes of the TLR4 pathway and their interaction...

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