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Article

Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.

Blood - 1 Mar 2004

Ameri Kurosh, Lewis Claire E, Raida Martin, Sowter Heidi, Hai Tsonwin, Harris Adrian L

Abstract excerpt

Hypoxia is a key factor in tumor development, contributing to angiogenesis and radiotherapy resistance. Hypoxia-inducible factor-1 (HIF-1) is a major transcription factor regulating the response of cancer cells to hypoxia. However, tumors also contain areas of more severe oxygen depletion, or anoxia. Mechanisms for survival under anoxia are HIF-1alpha independent in Caenorhabditis elegans and, thus, differ from...

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PMID: 14604972
DOI: 10.1182/blood-2003-06-1859

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VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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