Article
Functional constraints against variations on molecules from the tissue level: slowly evolving brain-specific genes demonstrated by protein kinase and immunoglobulin supergene families.
Molecular biology and evolution - 1 Jan 1995
Kuma K, Iwabe N, Miyata T
Abstract excerpt
In the protein kinase family, the basic function of kinase domain is similar among members. According to the standard view of functional constraint, the molecular evolutionary rate depends on functional and structural features characteristic of individual molecules (local constraint). Thus the ev...
Topics
- Animals
- Biological Evolution
- Brain
- Chromosome Mapping
- Genes
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Immunoglobulins
- Mice
- Multigene Family
- Neurons
- Organ Specificity
- Protein Kinases