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Article

Transcriptional activation of the type I collagen genes COL1A1 and COL1A2 in fibroblasts by interleukin‐4: Analysis of the functional collagen promoter sequences

28 Oct 2003

Abstract excerpt

Pneumonitis followed by lung fibrosis is a frequent complication of radiation therapy of chest tumors. A hallmark of these fibrotic lesions is the excessive production and accumulation of extracellular matrix proteins such as type I collagen. In addition to TGF-beta1, IL-4 has been recognized as a potent inducer of collagen gene synthesis in fibroblasts. In this study, we analyzed the regulation of the alpha1(I)...

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PMID: 14603527
DOI: 10.1002/jcp.10395

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