Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1.

doi:10.1042/bj3020471

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Article

Promoter elements in the transcriptional activation of the human stromelysin-1 gene by the inflammatory cytokine, interleukin 1.

The Biochemical journal - 1 Sept 1994

Quinones S, Buttice G, Kurkinen M

Abstract excerpt

Stromelysin-1, a tissue-remodelling metalloproteinase synthesized by fibroblasts, has proteolytic activity against a variety of extracellular matrix components. Stromelysin-1 gene transcription is induced by the inflammatory cytokine interleukin (IL)-1. In fibroblasts transiently transfected with constructs containing 5'-deletion mutants of the human stromelysin-1 gene promoter, IL-1-induced transcriptional...

Topics

Base Sequence
Binding Sites
Carcinoma, Hepatocellular
Cells, Cultured
Deoxyribonucleases
Electrophoresis, Polyacrylamide Gel
Fibroblasts
Genes, Reporter
Humans
Interleukin-1
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Matrix Metalloproteinase 3

Metalloendopeptidases

Molecular Sequence Data

Mutation

Plasmids

Promoter Regions, Genetic

Proto-Oncogene Proteins c-jun

Source

Open in PubMed Open full text

Identifiers

PMID: 8092999
DOI: 10.1042/bj3020471
PMCID: PMC1137252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8092999-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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