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Article

NF-kappaB induced by IL-1beta inhibits elastin transcription and myofibroblast phenotype.

American journal of physiology. Cell physiology - 1 Jul 2002

Kuang Ping-Ping, Berk John L, Rishikof David C, Foster Judith A, Humphries Donald E, Ricupero Dennis A, Goldstein Ronald H

Abstract excerpt

Interleukin (IL)-1beta released after lung injury regulates the production of extracellular matrix components. We found that IL-1beta treatment reduced the rate of elastin gene transcription by 74% in neonatal rat lung fibroblasts. Deletion analysis of the rat elastin promoter detected a cis-acting element located at -118 to -102 bp that strongly bound Sp1 and Sp3 but not nuclear factor (NF)-kappaB. This element...

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Identifiers

PMID: 12055073
DOI: 10.1152/ajpcell.00314.2001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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