Article
Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.
Neuron - 23 Jan 2003
Hendricks Timothy J, Fyodorov Dmitry V, Wegman Lauren J, Lelutiu Nadia B, Pehek Elizabeth A, Yamamoto Bryan, Silver Jerry, Weeber Edwin J, Sweatt J David, Deneris Evan S
Abstract excerpt
The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of...
Topics
- Aggression
- Alleles
- Animals
- Anxiety
- Behavior, Animal
- Biogenic Monoamines
- Carrier Proteins
- Cell Differentiation
- Chromatography, High Pressure Liquid
- Immunohistochemistry
- In Situ Hybridization
- Membrane Glycoproteins