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Article

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

Neuron - 23 Jan 2003

Hendricks Timothy J, Fyodorov Dmitry V, Wegman Lauren J, Lelutiu Nadia B, Pehek Elizabeth A, Yamamoto Bryan, Silver Jerry, Weeber Edwin J, Sweatt J David, Deneris Evan S

Abstract excerpt

The central serotonin (5-HT) neurotransmitter system is an important modulator of diverse physiological processes and behaviors; however, the transcriptional mechanisms controlling its development are largely unknown. The Pet-1 ETS factor is a precise marker of developing and adult 5-HT neurons and is expressed shortly before 5-HT appears in the hindbrain. Here we show that in mice lacking Pet-1, the majority of...

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PMID: 12546819
DOI: 10.1016/s0896-6273(02)01167-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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