Article

<i>LMX1B</i> missense-perturbation of regulatory element footprints disrupts serotonergic forebrain axon arborization

2024-12-13

Abstract excerpt

Pathogenic coding mutations are prevalent in human neuronal transcription factors (TFs) but how they disrupt development is poorly understood. Lmx1b is a master transcriptional regulator of postmitotic Pet1 neurons that give rise to mature serotonin (5-HT) neurons; over two hundred pathogenic heterozygous mutations have been discovered in human LMX1B, yet their impact on brain development has not been investigat...

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Literature Corpus work: 88c7dd97-8520-5c07-8576-bda692632153
DOI: 10.1101/2024.12.12.628165

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