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Article

A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila.

Developmental cell - 18 Oct 2011

Vrailas-Mortimer Alysia, del Rivero Tania, Mukherjee Subhas, Nag Sanjay, Gaitanidis Alexandros, Kadas Dimitris, Consoulas Christos, Duttaroy Atanu, Sanyal Subhabrata

Abstract excerpt

Molecular mechanisms that concordantly regulate stress, life span, and aging remain incompletely understood. Here, we demonstrate that in Drosophila, a p38 MAP kinase (p38K)/Mef2/MnSOD pathway is a coregulator of stress and life span. Hence, overexpression of p38K extends life span in a MnSOD-dependent manner, whereas inhibition of p38K causes early lethality and precipitates age-related motor dysfunction and...

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Identifiers

PMID: 22014527
DOI: 10.1016/j.devcel.2011.09.002
PMCID: PMC3199449

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