Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.

PLoS genetics - 1 Sept 2014

Chakrabarti Sveta, Poidevin Mickaël, Lemaitre Bruno

Abstract excerpt

The p38 mitogen-activated protein (MAP) kinase signaling cassette has been implicated in stress and immunity in evolutionarily diverse species. In response to a wide variety of physical, chemical and biological stresses p38 kinases phosphorylate various substrates, transcription factors of the ATF family and other protein kinases, regulating cellular adaptation to stress. The Drosophila genome encodes three p38...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activating Transcription Factor 2
Share to Bacterial Infections
Share to Disease Resistance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Host-Pathogen Interactions

Share to Intestinal Mucosa

Share to Lipid Metabolism

Share to p38 Mitogen-Activated Protein Kinases

Share to Peptide Chain Initiation, Translational

Source

Open in PubMed Open full text

Identifiers

PMID: 25254641
DOI: 10.1371/journal.pgen.1004659
PMCID: PMC4177744

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila MAPK p38c regulates oxidative stress and lipid homeostasis in the intestine.PMID 25254641Read ↗

A Drosophila p38 orthologue is required for environmental stress responses.Semantic proximity Read ↗

Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi.Semantic proximity Read ↗

Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans.Semantic proximity Read ↗

Comparative transcriptomics reveals CrebA as a novel regulator of infection tolerance in D. melanogasterSemantic proximity Read ↗

Enteric bacterial infection in <i>Drosophila</i> induces whole-body alterations in metabolic gene expression independently of the Immune Deficiency (Imd) signalling pathwaySemantic proximity Read ↗

Casein kinase 1 gamma integrates oxidative stress and innate immune responsesSemantic proximity Read ↗

Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence.Semantic proximity Read ↗

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila.Semantic proximity Read ↗

p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans.Semantic proximity Read ↗

Human pathogenic bacteria, fungi, and viruses inDrosophilaSemantic proximity Read ↗

MK2-dependent p38b signalling protects Drosophila hindgut enterocytes against JNK-induced apoptosis under chronic stress.Semantic proximity Read ↗

An essential role for XBP-1 in host protection against immune activation in C. elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.