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Article

Characterization of evolutionary rates and constraints in three Mammalian genomes.

Genome research - 1 Apr 2004

Cooper Gregory M, Brudno Michael, Stone Eric A, Dubchak Inna, Batzoglou Serafim, Sidow Arend

Abstract excerpt

We present an analysis of rates and patterns of microevolutionary phenomena that have shaped the human, mouse, and rat genomes since their last common ancestor. We find evidence for a shift in the mutational spectrum between the mouse and rat lineages, with the net effect being a relative increase in GC content in the rat genome. Our estimate for the neutral point substitution rate separating the two rodents is...

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Identifiers

PMID: 15059994
DOI: 10.1101/gr.2034704
PMCID: PMC383297

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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