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Article

Updates on the biology of serotonin and tryptophan hydroxylase

30 Nov 2017

Abstract excerpt

PURPOSE OF REVIEW: To summarize the most recent findings relevant to the biology of serotonin (5-hydroxytryptamine; 5-HT) and the enzyme tryptophan hydroxylase (TPH) in human gastrointestinal disease. RECENT FINDINGS: Serotonin is synthesized in the central nervous system (CNS) and the gastrointestinal tract where it is secreted from enteroendocrine cells. Its biosynthesis is regulated by two isoforms of the...

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PMID: 29194046
DOI: 10.1097/med.0000000000000383

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